
Diane S. Book, MD
Professor
Location
- Neuroscience Center – Specialty Clinics
- 900 N. 92nd St.
- Milwaukee, WI 53226
Specialties
- Behavioral Neurology
- Neurology
Neurology-Appointment by Referral Only
I approach patients from the perspective of doctor as teacher- as originally defined 700 years ago. I see every patient encounter as an opportunity to teach them how to heal, to recover, and how to stay well in the future.
Overview
Diseases and Conditions
- Alzheimer's Disease
- Alzheimer's-Related Dementias
- Aphasia
- Cerebrovascular Disease
- Dementia
- Ischemic Stroke
- Memory Disorders
- Memory Loss
- Stroke
- Transient Ischemic Attack
- CADASIL
- Degenerative Dementia
- Vascular Cognitive Impairment
- Frontal Temporal Dementia
- Lewy Body Dementia
- Cerebrovascular Accident (CVA)
- Stroke from Intracranial Atherosclerotic Disease or Carotid Disease
- TIA from Intracranial Atherosclerotic Disease or Carotid Disease
Treatments and Services
- Acute Stroke Therapy
- Evaluation and Managment of Degenerative Dementias
- Stroke Evaluation and Management
- Virtual Visit
Patients Ages Seen
- Adult
- Senior
Languages
- English
Hospital Affiliations
- Froedtert Hospital – Milwaukee
Board Certifications
- Neurology
Clinic Locations
- 900 N. 92nd St.
- Milwaukee, WI 53226
- (414) 805-5400

Biography
Dr. Book is a specialist in cerebrovascular disorders including stroke, having co-founded the Froedtert & the 91ɫƵ Stroke Program, and also in the dementias including Alzheimer’s Disease and vascular cognitive disorders. She has expanded her interests in stroke care quality to encompass patient safety and quality across Neurology.
Education and Training
Doctor of Medicine - 91ɫƵ - Milwaukee, WI (1991)
Residency in Neurology - 91ɫƵ - Milwaukee, WI (1995)
Fellowship in Stroke/Dementia - 91ɫƵ Affiliated Hospitals - Milwaukee, WI (1996)
Certificate in LEAN Healthcare - University of Michigan - Ann Arbor, MI (2013)
Publications
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(Sieck DC, Kobak SH, Larson EA, Dreyer HC, Fogarty MJ, Sieck GC, Minson CT, Halliwill JR.) J Appl Physiol (1985). 2025 Jun 01;138(6):1398-1410 PMID: 40372922 05/15/2025
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(Binder JR, Freiberg A, Heffernan J, Giraldo-Chica M, Book DS, Pillay SB.) Brain. 2025 Apr 03;148(4):1421-1434 PMID: 39789712 SCOPUS ID: 2-s2.0-105003923504 01/10/2025
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(Lisa Baumann Kreuziger, Hatim Attar, Diane Book, Ashley Cunningham, Alexandra Harrington, Jacob Janssen, Julie Kolinski, Benjamin Jung, Nathan Ledeboer, Jennifer McIntosh, Siddhartha Singh .) the 33rd Congress of the International Society on Thrombosis and Haemostasis to be held in Washington, D.C., U.S. from June 21 – 25, 2025. . 06/21/2025
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(Pillay SB, Gross WL, Heffernan J, Book DS, Binder JR.) Brain Lang. 2022 Oct;233:105164 PMID: 35933744 PMCID: PMC9948519 SCOPUS ID: 2-s2.0-85135407900 08/08/2022
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(Pillay SB, Gross WL, Graves WW, Humphries C, Book DS, Binder JR.) J Cogn Neurosci. 2018 Apr;30(4):514-525 PMID: 29211656 PMCID: PMC9926535 SCOPUS ID: 2-s2.0-85042764522 12/07/2017
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(Pillay SB, Binder JR, Humphries C, Gross WL, Book DS.) Neurology. 2017 Mar 07;88(10):970-975 PMID: 28179469 PMCID: PMC5333516 SCOPUS ID: 2-s2.0-85014816931 02/10/2017
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(Binder JR, Pillay SB, Humphries CJ, Gross WL, Graves WW, Book DS.) Brain. 2016 May;139(Pt 5):1517-26 PMID: 26966139 PMCID: PMC5006249 SCOPUS ID: 2-s2.0-84966648862 03/12/2016
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(Pillay SB, Stengel BC, Humphries C, Book DS, Binder JR.) Ann Neurol. 2014 Nov;76(5):738-46 PMID: 25164766 PMCID: PMC4214892 SCOPUS ID: 2-s2.0-84912085803 08/29/2014
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(Carroll JD, Saver JL, Thaler DE, Smalling RW, Berry S, MacDonald LA, Marks DS, Tirschwell DL, RESPECT Investigators.) N Engl J Med. 2013 Mar 21;368(12):1092-100 PMID: 23514286 03/22/2013
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(SPS3 Investigators, Benavente OR, Hart RG, McClure LA, Szychowski JM, Coffey CS, Pearce LA.) N Engl J Med. 2012 Aug 30;367(9):817-25 PMID: 22931315 PMCID: PMC4067036 08/31/2012
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(Amarenco P, Bogousslavsky J, Callahan A 3rd, Goldstein LB, Hennerici M, Rudolph AE, Sillesen H, Simunovic L, Szarek M, Welch KM, Zivin JA, Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators.) N Engl J Med. 2006 Aug 10;355(6):549-59 PMID: 16899775 08/11/2006
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(Varelas PN, Sinson G, Rand S, Book D.) Neurology. 2005 Jan 25;64(2):393-4 PMID: 15668456 SCOPUS ID: 2-s2.0-12544250987 01/26/2005