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I grew up in Mobile, AL, the birthplace of US Mardi Gras. I received my Bachelor of Science in Microbial, Molecular, and Cellular Biology from Auburn University, where I discovered a love for microorganisms, particularly those with properties beneficial to humans. I joined University of Florida’s Interdisciplinary Program in Biomedical Sciences for my PhD with the intention of studying bacteria, but quickly realized Florida was a world leader in virus-mediated gene therapy. While deciding on labs to rotate, I was shown an fluorescent microscopy image of a retina expressing green fluorescent protein in photoreceptors and immediately fell in love; it was the most beautiful scientific image I had even seen by that point in my career and I desperately wanted to take similar images. I joined Dr. Shannon Boye's lab, developing adeno associated viruses to target retinal bipolar cells, which receive photoreceptor signals. After graduating in 2016, I joined Dr. Aravind Asokan’s lab as a postdoctoral fellow in the Gene Therapy Center at University of North Carolina- Chapel Hill, where I worked on strategies to enable more robust gene expression from gene therapy vectors. However, I missed the retina, so I moved to Dr. Greg Field’s lab at Duke University, then University of California Los Angeles, to investigate retinal circuitry changes during retinal disease and following therapy using multielectrode arrays to record retinal output. Being in the Field Lab gave me ample opportunity to develop new techniques to interrogate retinal function: we pioneered a prey capture task to assess vision loss in animals with retinitis pigmentosa, utilized novel chemogenetic strategies to modify retinal function (where my gene therapy skills finally became useful to the lab), and created the first transcriptome of rewiring bipolar cells during retinitis pigmentosa and following gene therapy.

Best Postdoc Talk, Duke Neurobiology Annual Retreat, 2022
Travel Award, Association for Research in Vision and Ophthalmology, 2020, 2021, 2022
Fellowship, Association for Research in Vision and Ophthalmology Science Communication, 2021- 2022
Duke School of Medicine Interdisciplinary Colloquia Award (co-PI), 2019
Best Postdoc Poster, Duke Neurobiology Retreat, 2019
Scholarship, Foundation Fighting Blindness tuition award to attend CSHL course, 2019
Duke Postdoctoral Award for Professional Development, 2019
Holland-Trice Scholars Award (co-PI), 2018-2020
Travel Award, American Society of Gene & Cell Therapy Annual Meeting, 2015, 2017
Travel Award, University of Florida Graduate Student Council, 2015
Semi-finalist Advancement to Candidacy Award, University of Florida Medical Guild, 2015
Fellow, National Eye Institute Vision Sciences T32 Training Grant, University of Florida, 2014-2016
Travel Award, FASEB Retinal Neurobiology and Visual Processing, 2014

The Scalabrino Lab aims to distinguish between the positive and negative changes the retina undergoes as a reaction to inherited disease impacting vision. By harnessing adaptive mechanisms, we can develop biological therapies to halt blindness and restore vision in patients with inherited retinal diseases like retinitis pigmentosa and congenital stationary night blindness. We use a variety of techniques to accomplish this goal, aiming for a wholistic picture of retinal health and function. These include electrophysiology (multielectrode array retina recordings, electroretinography), live animal retinal imaging (optimal coherence tomography, fundoscopy), histology (confocal microscopy), molecular biology (viral vectors, RNA sequencing), and behavior (prey capture).