Matthew Kudek, MD

91九色视频

Assistant Professor, Pediatrics (Hematology/Oncology/BMT) and Microbiology & Immunology

Locations

MACC Fund Research Center
Room 5001

Contact Information

Education

MD, University of Wisconsin-Madison, 2014

                
                    Research Areas of Interest
                

                    Adaptive Immunity
Graft vs Host Disease
Host-Pathogen Interactions
Immunity, Innate
immunology
Immunotherapy, Adoptive
Listeria monocytogenes
Neoplasms
Neuroblastoma
T-Lymphocytes

            

                
                    Research Experience
                

                    Bone Marrow Transplantation
Cloning, Molecular
Flow Cytometry
Models, Animal
Primary Cell Culture
Sequence Analysis, RNA
Single-Cell Analysis
Transduction, Genetic

            

                
                    Clinical Expertise
                

                    Medical Oncology
Pediatrics
Precision Medicine

            

                
                    Methodologies and Techniques
                

                    Adoptive Transfer
Cell Culture Techniques
Cell Transformation, Viral
Cloning, Molecular
Flow Cytometry
Genotyping Techniques
Hematopoietic Stem Cell Transplantation
Histology
Single-Cell Analysis
Transcriptome
Transplantation, Homologous

            

Research Interests

We are interested in understanding the inappropriate immune responses that occur in cancer and immunotherapy. Allogeneic hematopoietic stem cell transplantation is the fundamental cancer-directed immunotherapy, but is often limited by highly morbid and frequently fatal graft versus host disease. Our lab is studying signaling mechanisms that occur in GVHD between innate and adaptive cellular components of the engrafting immune system. For this, we use mouse models of bone marrow transplantation. We hope to leverage the knowledge gained about intra- and intercellular signaling in GVHD to design novel immunotherapy approaches and pilot preclinical studies.

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