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Cell Biology, Neurobiology and Anatomy (CBNA)
Phillip A. Doerfler, PhD

Phillip A. Doerfler, PhD

Assistant Professor

Locations

  • Versiti Blood Research Institute

  • 8733 W. Watertown Plank Road
    Milwaukee, WI 53226

Contact Information

Education

Postdoc, Hematology, St. Jude Children鈥檚 Research Hospital, Memphis, TN, 2022
PhD, Genetics, University of Florida, Gainesville, FL, 2015
BS, cum laude, Biology, Hillsdale College, Hillsdale, MI, 2010

Research Interests

My lab鈥檚 long-term research is to enhance genetic therapies by understanding how genes are regulated and how genomes remain stable. We鈥檙e focusing on two key areas: the functional genomics of hemoglobin switching, which improves our clinical and biological understanding of 尾-hemoglobinopathies and studying how blood stem cells respond to DNA damage, particularly from genome editing tools like CRISPR-Cas9. This work is crucial for improving the safety and effectiveness of genetic therapies. Functional genomics of hemoglobin switching Hemoglobin switching is the developmental process where different globin genes are activated at specific stages. Around six months after birth, the fetal 纬-globin genes are silenced and the adult 尾-globin gene is activated, which prompts symptoms of 尾-hemoglobinopathies like sickle cell disease and 尾-thalassemia. By studying this switching mechanism, we aim to develop therapies that reactivate 纬-globin to treat these conditions. Our research focuses on the genetic elements involved in this switch and how this knowledge can inform genome editing strategies for effective treatments.

Publications

  • (Mayuranathan T, Newby GA, Feng R, Yao Y, Mayberry KD, Lazzarotto CR, Li Y, Levine RM, Nimmagadda N, Dempsey E, Kang G, Porter SN, Doerfler PA, Zhang J, Jang Y, Chen J, Bell HW, Crossley M, Bhoopalan SV, Sharma A, Tisdale JF, Pruett-Miller SM, Cheng Y, Tsai SQ, Liu DR, Weiss MJ, Yen JS.) Nat Genet. 2023 Jul;55(7):1210-1220 PMID: 37400614 PMCID: PMC10722557 07/04/2023

  • (Feng R, Mayuranathan T, Huang P, Doerfler PA, Li Y, Yao Y, Zhang J, Palmer LE, Mayberry K, Christakopoulos GE, Xu P, Li C, Cheng Y, Blobel GA, Simon MC, Weiss MJ.) Nature. 2022 Oct;610(7933):783-790 PMID: 36224385 PMCID: PMC9773321 10/13/2022

  • (Woodard KJ, Doerfler PA, Mayberry KD, Sharma A, Levine R, Yen J, Valentine V, Palmer LE, Valentine M, Weiss MJ.) Dis Model Mech. 2022 Jun 01;15(6) PMID: 35793591 PMCID: PMC9277148 07/07/2022

  • (Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA.) Nat Genet. 2022 Jun;54(6):906 PMID: 35650318 06/02/2022

  • (Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA.) Nat Genet. 2022 Jun;54(6):874-884 PMID: 35618846 PMCID: PMC9203980 05/27/2022

  • (Doerfler PA, Feng R, Li Y, Palmer LE, Porter SN, Bell HW, Crossley M, Pruett-Miller SM, Cheng Y, Weiss MJ.) Nat Genet. 2021 Aug;53(8):1177-1186 PMID: 34341563 PMCID: PMC8610173 08/04/2021

  • (Leibowitz ML, Papathanasiou S, Doerfler PA, Blaine LJ, Sun L, Yao Y, Zhang CZ, Weiss MJ, Pellman D.) Nat Genet. 2021 Jun;53(6):895-905 PMID: 33846636 PMCID: PMC8192433 04/14/2021

  • (Doerfler PA, Sharma A, Porter JS, Zheng Y, Tisdale JF, Weiss MJ.) J Clin Invest. 2021 Apr 15;131(8) PMID: 33855970 PMCID: PMC8262557 04/16/2021

  • (Doyle BM, Turner SMF, Sunshine MD, Doerfler PA, Poirier AE, Vaught LA, Jorgensen ML, Falk DJ, Byrne BJ, Fuller DD.) Mol Ther Methods Clin Dev. 2019 Dec 13;15:194-203 PMID: 31660421 PMCID: PMC6807287 10/30/2019

  • (Métais JY, Doerfler PA, Mayuranathan T, Bauer DE, Fowler SC, Hsieh MM, Katta V, Keriwala S, Lazzarotto CR, Luk K, Neel MD, Perry SS, Peters ST, Porter SN, Ryu BY, Sharma A, Shea D, Tisdale JF, Uchida N, Wolfe SA, Woodard KJ, Wu Y, Yao Y, Zeng J, Pruett-Miller S, Tsai SQ, Weiss MJ.) Blood Adv. 2019 Nov 12;3(21):3379-3392 PMID: 31698466 PMCID: PMC6855127 11/08/2019

  • (Doerfler PA, Nayak S, Corti M, Morel L, Herzog RW, Byrne BJ.) Mol Ther Methods Clin Dev. 2016;3:15053 PMID: 26858964 PMCID: PMC4729315 02/10/2016

  • (Doerfler PA, Todd AG, Clément N, Falk DJ, Nayak S, Herzog RW, Byrne BJ.) Hum Gene Ther. 2016 Jan;27(1):43-59 PMID: 26603344 PMCID: PMC4741206 11/26/2015

Publications of from the

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