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Cell Biology, Neurobiology and Anatomy (CBNA)
John D. McCorvy, PhD

John D. McCorvy, PhD

Associate Professor

Locations

  • Cell Biology, Neurobiology and Anatomy

Contact Information

Education

Postdoctoral, Pharmacology, University of NC-Chapel Hill, 2018
PhD, Medicinal Chemistry and Molecular Pharmacology, Purdue University, 2012
BA, Biochemistry and Psychology, Texas Tech University, 2005

Research Interests

  • Molecular and Structural Pharmacology of G protein-coupled Receptors (GPCRs)
  • Structure-based Design and Discovery of GPCR Drugs
  • Study of Biased Agonism and Pathway-Selective Compounds for GPCRs
  • Psychedelic Drug Action at the Serotonin GPCRs
  • Molecular Determinants of Opioid Receptor Signaling and Efficacy
  • Medicinal Chemistry and Structure-Activity Relationships for Psychoactive Drugs
  • Antipsychotic Polypharmacology
  • High-throughput Screening (HTS) Technologies and Assay Development
  • Protein Conformation Dynamics and Structure Determination

Publications

  • (Wacker D, McCorvy JD.) Annu Rev Pharmacol Toxicol. 2025 Aug 12 PMID: 40796124 08/13/2025

  • (Aarrestad IK, Cameron LP, Fenton EM, Casey AB, Rijsketic DR, Patel SD, Sambyal R, Johnson SB, Ly C, Viswanathan J, Barragan EV, Lozano SA, Seban N, Hu H, Powell NA, Chytil M, Meyer R, Rose D, Hempel C, Olson E, Hansen HD, Madsen CA, Knudsen GM, Redd C, Wheeler DG, Guanzon N, Muir J, Hennessey JJ, Quon G, McCorvy JD, Gandhi SP, Rasmussen K, Liston C, Gray JA, Heifets BD, Nord AS, Kim CK, Olson DE.) Nat Neurosci. 2025 Aug 04 PMID: 40760185 PMCID: PMC12373294 08/05/2025

  • (Zajdel P, Mat艂oka M, Konieczny J, Kos T, Lammers JC, Cavalco NG, Clark AA, Lenda T, Sata艂a G, Canale V, Grychowska K, Krawczyk M, Nikiforuk A, Partyka A, Jastrz臋bska-Wi臋sek M, Berghauzen-Maciejewska K, Bia艂a D, Janicka M, Janusz A, Piast R, Mulewski K, Smuga D, Pieczykolan J, Wieczorek M, Moszczy艅ski-P臋tkowski R, Dubiel K, Ossowska K, Bojarski AJ, Kami艅ski K, McCorvy JD, Popik P.) J Pharmacol Exp Ther. 2025 Feb;392(2):100055 PMID: 40023605 SCOPUS ID: 2-s2.0-85218008513 03/03/2025

  • (Zajdel P, Mat艂oka M, Konieczny J, Kos T, Lammers JC, Cavalco NG, Clark AA, Lenda T, Sata艂a G, Canale V, Grychowska K, Krawczyk M, Nikiforuk A, Partyka A, Jastrz臋bska-Wi臋sek M, Berghauzen-Maciejewska K, Bia艂a D, Janicka M, Janusz A, Piast R, Mulewski K, Smuga D, Pieczykolan J, Wieczorek M, Moszczy艅ski-P臋tkowski R, Dubiel K, Ossowska K, Bojarski AJ, Kami艅ski K, McCorvy JD, Popik P.) Journal of Pharmacology and Experimental Therapeutics. February 2025;392(2) SCOPUS ID: 2-s2.0-85218008513 02/01/2025

  • (Glatfelter GC, Clark AA, Cavalco NG, Landavazo A, Partilla JS, Naeem M, Golen JA, Chadeayne AR, Manke DR, Blough BE, McCorvy JD, Baumann MH.) ACS Chem Neurosci. 2024 Dec 18;15(24):4458-4477 PMID: 39636099 SCOPUS ID: 2-s2.0-85211348154 12/05/2024

  • (Tosh DK, Pavan M, Clark AA, Lammers J, Villano S, Marri S, Sgambellone S, Choi S, Lee J, Ivancich MS, Bock HA, Campbell RG, Lewicki SA, Levitan IM, Chen E, Liu N, Demby T, Gavrilova O, Gao ZG, Lucarini L, McCorvy JD, Jacobson KA.) J Med Chem. 2024 Dec 12;67(23):21264-21291 PMID: 39589936 PMCID: PMC11715225 SCOPUS ID: 2-s2.0-85210269617 11/26/2024

  • (Alberto-Silva AS, Hemmer S, Bock HA, da Silva LA, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH.) J Neurochem. 2024 Sep;168(9):2022-2042 PMID: 38898705 PMCID: PMC11449655 SCOPUS ID: 2-s2.0-85196430944 06/20/2024

  • (Denomme N, Hernandez CC, Bock HA, Ohana RF, Bakshi S, Sherwood AM, McCorvy JD, Daley PF, Callaway WB, Hull JM, Alt A, Isom LL, Cozzi NV.) Mol Pharmacol. 2024 Jul 17;106(2):92-106 PMID: 38821630 PMCID: PMC11254453 SCOPUS ID: 2-s2.0-85199223647 06/01/2024

  • (Schlimgen RR, Peterson FC, Heukers R, Smit MJ, McCorvy JD, Volkman BF.) Nat Commun. 2024 May 30;15(1):4611 PMID: 38816420 PMCID: PMC11139983 SCOPUS ID: 2-s2.0-85194992751 05/31/2024

  • (Alberto-Silva AS, Hemmer S, Bock HA, Alves da Silva L, Scott KR, Kastner N, Bhatt M, Niello M, Jäntsch K, Kudlacek O, Bossi E, Stockner T, Meyer MR, McCorvy JD, Brandt SD, Kavanagh P, Sitte HH.) bioRxiv. 2024 Apr 11 PMID: 38645142 PMCID: PMC11030374 04/22/2024

  • (Rodriguez P, Laskowski LJ, Pallais JP, Bock HA, Cavalco NG, Anderson EI, Calkins MM, Razzoli M, Sham YY, McCorvy JD, Bartolomucci A.) J Biol Chem. 2024 Jan;300(1):105549 PMID: 38072064 PMCID: PMC10796979 SCOPUS ID: 2-s2.0-85181819143 12/11/2023

  • (Wallach J, Cao AB, Calkins MM, Heim AJ, Lanham JK, Bonniwell EM, Hennessey JJ, Bock HA, Anderson EI, Sherwood AM, Morris H, de Klein R, Klein AK, Cuccurazzu B, Gamrat J, Fannana T, Zauhar R, Halberstadt AL, McCorvy JD.) Nat Commun. 2023 Dec 15;14(1):8221 PMID: 38102107 PMCID: PMC10724237 SCOPUS ID: 2-s2.0-85179903706 12/16/2023

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