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Cardiovascular Research Center

David X. Zhang Lab

Zhang Lab
David X. Zhang, PhD

David X. Zhang, PhD
Associate Professor, Department of Medicine
xfzhang@mcw.edu

The overall emphasis of the Zhang laboratory is to understand signaling mechanisms in the regulation of blood vessel reactivity and homeostasis under normal states as well as in diseases such as coronary artery disease (CAD), hypertension, and diabetes. A major effort of my laboratory is to understand how ion channels and related signaling molecules regulate flow- and agonist-mediated dilation of human arterioles from subjects with and without CAD. The current research is focused on the role of transient receptor potential (TRP) channels, especially TRPV4 channels, in mediating the conversion of vasodilator factors (NO/PGI2 in health and H2O2 in disease) in the human microcirculation. A second line of research relates to the function of smooth muscle K+ channels, such as Ca2+-activated K+ (KCa) and voltage-gated K+ (KV) channels, in arterioles from subjects with and without CAD. These smooth muscle K+ channels are the key end-effector of vasomotor control in the microcirculation. Studies are performed with an integrated approach ranging from cellular and molecular techniques (Ca2+ imaging, protein mutagenesis), electrophysiology (patch clamping), to isolated vessel reactivity and in vivo vascular function assays.

Lab Members

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Konstantin Drachuk, PhD

Mentor: David Zhang, PhD

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Aravind Parthasarathy, PhD

Mentor: David Zhang, PhD

Recent Publications

  • (Parthasarathy A, Anishkin A, Xie Y, Drachuk K, Nishijma Y, Fang J, Koukouritaki SB, Wilcox DA, Zhang DX.) J Biol Chem. 2025 Mar;301(3):108260 PMID: 39909371 PMCID: PMC11903807 SCOPUS ID: 2-s2.0-85218338007 02/06/2025

  • (Zinkevich NS, Drachuk K, Zhang DX.) Vascul Pharmacol. 2024 Dec;157:107440 PMID: 39537001 PMCID: PMC11624973 SCOPUS ID: 2-s2.0-85208761085 11/14/2024

  • (Kosuru R, Romito O, Sharma GP, Ferraresso F, Ghadrdoost Nakhchi B, Yang K, Mammoto T, Mammoto A, Kastrup CJ, Zhang DX, Goldspink PH, Trebak M, Chrzanowska M.) Arterioscler Thromb Vasc Biol. 2024 Nov;44(11):2271-2287 PMID: 39324266 PMCID: PMC11495542 SCOPUS ID: 2-s2.0-85206451357 09/26/2024

  • (Nadezhdin KD, Talyzina IA, Parthasarathy A, Neuberger A, Zhang DX, Sobolevsky AI.) Nat Commun. 2023 Jun 23;14(1):3733 PMID: 37353478 PMCID: PMC10290124 SCOPUS ID: 2-s2.0-85162777271 06/24/2023

  • (Sylvester AL, Zhang DX, Ran S, Zinkevich NS.) Biomolecules. 2022 Jun 13;12(6) PMID: 35740948 PMCID: PMC9221095 SCOPUS ID: 2-s2.0-85131782032 06/25/2022

  • (Xie Y, Nishijima Y, Zinkevich NS, Korishettar A, Fang J, Mathison AJ, Zimmermann MT, Wilcox DA, Gutterman DD, Shen Y, Zhang DX.) Basic Res Cardiol. 2022 Apr 25;117(1):24 PMID: 35469044 PMCID: PMC9119129 SCOPUS ID: 2-s2.0-85128849246 04/27/2022

  • (Nishijima Y, Hader SN, Hanson AJ, Zhang DX, Sparapani R, Gutterman DD, Beyer AM.) Cardiovasc Res. 2022 Jan 07;118(1):18-19 PMID: 34755839 PMCID: PMC8689948 SCOPUS ID: 2-s2.0-85123651313 11/11/2021

  • (Singh B, Kosuru R, Lakshmikanthan S, Sorci-Thomas MG, Zhang DX, Sparapani R, Vasquez-Vivar J, Chrzanowska M.) Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):638-650 PMID: 33267664 PMCID: PMC8105264 SCOPUS ID: 2-s2.0-85104181830 12/04/2020

  • (Korishettar AM, Nishijima Y, Wang Z, Xie Y, Fang J, Wilcox DA, Zhang DX.) Br J Pharmacol. 2021 Feb;178(3):709-725 PMID: 33184836 PMCID: PMC9121782 SCOPUS ID: 2-s2.0-85098221966 11/14/2020

  • (Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M.) Front Cell Dev Biol. 2021;9:741935 PMID: 34422844 PMCID: PMC8378398 08/24/2021

  • (Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M.) Front Cell Dev Biol. 2021;9:687598 PMID: 34222255 PMCID: PMC8247587 07/06/2021

  • (Zhang DX, Gutterman DD.) Arterioscler Thromb Vasc Biol. 2019 Dec;39(12):2454-2456 PMID: 31770031 PMCID: PMC6980742 SCOPUS ID: 2-s2.0-85075688768 11/27/2019

Publications of from the

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