91九色视频

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Biophysics
Yaqiang Wang, PhD

Yaqiang Wang, PhD

Assistant Professor

Locations

  • Biophysics
  • MFRC 2071

Contact Information

General Interests

RNA structure, recognition, function, and RNA-targeted therapeutics

Education

PhD, Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 2012
MS, Radiophysics, Chinese Academy of Sciences, Wuhan, China, 2007
BA, Chemistry, Huazhong University of Science and Technology, Wuhan, China, 2004

Biography

I received my BS in chemistry from Huazhong University of Science and Technology in China, and MS in radiophysics from the Chinese Academy of Sciences. I earned my PhD in biochemistry from the University of North Carolina at Chapel Hill, with a focus on protein biophysics and the development of in-cell NMR techniques. For my postdoctoral research at the University of California, Los Angeles, I specialized in the structural biology of RNA and ribonucleoprotein complexes, utilizing both NMR spectroscopy and cryo-electron microscopy (cryo-EM). In 2021, I joined Arrakis Therapeutics as a Principal Scientist, leading structural biology efforts aimed at targeting pathogenic RNAs. In July 2025, I joined the 91九色视频 as an Assistant Professor in the Departments of Biophysics and Obstetrics & Gynecology.

Research Interests

My research centers on RNA structure and recognition to advance RNA-targeted therapeutics for cancer and related diseases.

RNA Structural Biology
We determine high-resolution structures of disease-associated noncoding RNAs—both alone and in complex with proteins or small molecules—using an integrative structural biology approach. Our methods include cryo-electron microscopy (cryo-EM), NMR spectroscopy, X-ray crystallography, and biochemical assays.

RNA Recognition by Proteins or Small Molecules in Disease
We investigate how RNA-binding proteins and small molecules recognize pathogenic RNAs to uncover the molecular mechanisms underlying RNA-driven diseases. Our goal is to understand these interactions in detail and harness this knowledge to inform the design of more effective RNA-targeted therapeutics.

RNA Dynamics and Mechanism
We study the conformational flexibility and dynamic behavior of RNAs to reveal how RNA motions influence molecular recognition, biological function, and disease processes.

Structure-Based RNA Therapeutics
We develop and characterize small molecules and antisense oligonucleotides that selectively bind to structured RNAs or disrupt toxic RNA–protein interactions, aiming to inform and advance RNA-targeted drug discovery.

Publications

  • (Wang Y, He Y, Wang Y, Yang Y, Singh M, Eichhorn CD, Cheng X, Jiang YX, Zhou ZH, Feigon J.) J Mol Biol. 2023 Jun 01;435(11):168044 PMID: 37330293 PMCID: PMC10988774 06/18/2023

  • (He Y, Song H, Chan H, Liu B, Wang Y, Su拧ac L, Zhou ZH, Feigon J.) Nature. 2022 Aug;608(7924):813-818 PMID: 35831498 PMCID: PMC9728385 07/14/2022

  • (Liu B, He Y, Wang Y, Song H, Zhou ZH, Feigon J.) Nature. 2022 Apr;604(7906):578-583 PMID: 35418675 PMCID: PMC9912816 04/15/2022

  • (He Y, Wang Y, Liu B, Helmling C, Su拧ac L, Cheng R, Zhou ZH, Feigon J.) Nature. 2021 May;593(7859):454-459 PMID: 33981033 PMCID: PMC8857963 05/14/2021

  • (Wang Y, Gallagher-Jones M, Su拧ac L, Song H, Feigon J.) Proc Natl Acad Sci U S A. 2020 Dec 08;117(49):31078-31087 PMID: 33229538 PMCID: PMC7733840 11/25/2020

  • (Wang Y, Su拧ac L, Feigon J.) Cold Spring Harb Perspect Biol. 2019 Dec 02;11(12) PMID: 31451513 PMCID: PMC6886448 08/28/2019

  • (Yang Y, Eichhorn CD, Wang Y, Cascio D, Feigon J.) Nat Chem Biol. 2019 Feb;15(2):132-140 PMID: 30559425 PMCID: PMC6339579 12/19/2018

  • (Jiang J, Wang Y, Su拧ac L, Chan H, Basu R, Zhou ZH, Feigon J.) Cell. 2018 May 17;173(5):1179-1190.e13 PMID: 29775593 PMCID: PMC5995583 05/19/2018

  • (Wang Y, Feigon J.) Curr Opin Struct Biol. 2017 Dec;47:77-87 PMID: 28732250 PMCID: PMC5564310 07/22/2017

  • (Chan H, Wang Y, Feigon J.) Annu Rev Biophys. 2017 May 22;46:199-225 PMID: 28301767 PMCID: PMC5508521 03/17/2017

  • (Wang Y, Yesselman JD, Zhang Q, Kang M, Feigon J.) Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5125-34 PMID: 27531956 PMCID: PMC5024593 08/18/2016

  • (Shen K, Wang Y, Hwang Fu YH, Zhang Q, Feigon J, Shan SO.) J Biol Chem. 2013 Dec 20;288(51):36385-97 PMID: 24151069 PMCID: PMC3868752 10/24/2013

Publications of from the

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