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Biophysics
Francesa Marassi, PhD

Francesca M. Marassi, PhD

Professor, Chair, and Eminent Scholar; Associate Director, 91九色视频 Cancer Center Shared Resources

Locations

  • Biophysics
    MFRC 2034

Contact Information

General Interests

Structure and function of protein-lipid assemblies

Education

Postdoctoral Fellow of the Medical Research Council (MRC) of Canada, University of Pennsylvania, Philadelphia, PA, 1995-1998
Postdoctoral Fellow of the Natural Sciences and Engineering Research Council (NSERC) of Canada, University of Pennsylvania, Philadelphia, PA, 1993-1995
PhD, Physical Chemistry, University of Toronto, Toronto, Canada, 1993
MSc, Chemistry, University of Toronto, Toronto, Canada, 1989
BSc, Chemistry, University of Toronto, Toronto, Canada, 1987

Biography

I received my BS and MSc in chemistry and PhD in physical chemistry from University of Toronto in Canada. I was a postdoctoral fellow of the Medical Research Council of Canada and a postdoctoral fellow of the Natural Sciences and Engineering Research of Canada at University of Pennsylvania. My first faculty appointment was at the University of Pennsylvania Wistar Institute. I went on to hold faculty and administrative appointments at Sanford Burnham Prebys Medical Discovery Institute. I was appointed professor and chair of the 91九色视频 Department of Biophysics in 2022 and associate director of shared resources at the 91九色视频 Cancer Center in 2023.

Research Interests

Description of Research
My lab is interested in understanding the molecular basis of disease. We focus on the structures and functions of protein-lipid assemblies relevant in host-pathogen interactions, degenerative diseases of aging, and cancer-related programmed cell death. We work with samples that are close representatives of the native environment to establish authentic structure-activity profiles that can advance therapy development.

View the 91九色视频 Project Wonder piece on my lab's research into age-related macular degeneration.

Lab Members
Swapna Bera, PhD, Postdoctoral Researcher
Alyssa Kraft, Graduate Student
Rajlaxmi Panigrahi, PhD, Postdoctoral Researcher
Karthika Samimuthu, Research Associate
Kyungsoo Shin, PhD, Assistant Professor
Gopinath Tata, PhD, Assistant Professor
Nicholas Wood, PhD, Postdoctoral Researcher


Publications

  • (Wood NA, Kraft A, Shin K, Gopinath T, Marassi FM.) Proc Natl Acad Sci U S A. 2025 Jul;122(26):e2501638122 PMID: 40553494 PMCID: PMC12232643 SCOPUS ID: 2-s2.0-105009868499 06/24/2025

  • (Gopinath T, Kraft A, Shin K, Wood NA, Marassi FM.) J Biomol NMR. 2025 Mar;79(1):35-45 PMID: 39881117 SCOPUS ID: 2-s2.0-85217365606 01/30/2025

  • (Marassi FM, Pintacuda G.) Current Opinion in Structural Biology. October 2025;94 SCOPUS ID: 2-s2.0-105012732964 10/01/2025

  • (Dehinwal R, Gopinath T, Smith RD, Ernst RK, Schifferli DM, Waldor MK, Marassi FM.) Nat Commun. 2024 Aug 13;15(1):6958 PMID: 39138228 PMCID: PMC11322160 SCOPUS ID: 2-s2.0-85201246120 08/14/2024

  • (Gopinath T, Shin K, Tian Y, Im W, Struppe J, Perrone B, Hassan A, Marassi FM.) J Struct Biol. 2024 Mar;216(1):108061 PMID: 38185342 PMCID: PMC10939839 SCOPUS ID: 2-s2.0-85182378487 01/08/2024

  • (Kent JE, Ackermann BE, Debelouchina GT, Marassi FM.) Biochemistry. 2023 Aug 01;62(15):2252-2256 PMID: 37459255 PMCID: PMC11019665 SCOPUS ID: 2-s2.0-85166390720 07/17/2023

  • (Kent JE, Ackermann BE, Debelouchina GT, Marassi FM.) bioRxiv. 2023 May 18 PMID: 37292594 PMCID: PMC10245764 06/09/2023

  • (Shin K, Kent JE, Aleshin AE, Tian Y, Fujimoto LM, Singh C, Marassi FM.) Biophys J. 2023 Feb 10;122(3S1):467a PMID: 36784398 02/15/2023

  • (Tian Y, Shin K, Aleshin AE, Im W, Marassi FM.) Biophys J. 2022 Oct 18;121(20):3896-3906 PMID: 36056555 PMCID: PMC9674982 SCOPUS ID: 2-s2.0-85137693880 09/04/2022

  • (Zhang L, Kent JE, Whitaker M, Young DC, Herrmann D, Aleshin AE, Ko YH, Cingolani G, Saad JS, Moody DB, Marassi FM, Ehrt S, Niederweis M.) Nat Commun. 2022 Apr 26;13(1):2255 PMID: 35474308 PMCID: PMC9042941 SCOPUS ID: 2-s2.0-85128924949 04/28/2022

Publications of from the

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