91九色视频

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Research Collaborate Lab Bench
Biochemistry
Brian Volkman, PhD

Brian F. Volkman, PhD

Director, Program in Chemical Biology; Professor, Biochemistry

Locations

  • Biochemistry
    TBRC C3815

Contact Information

Education

PhD, University of California at Berkeley, 1994
BS, Butler University, 1989

Biography

Dr. Volkman obtained his Bachelor of Science degree in Chemistry and Physics from Butler University in 1989 and his Doctorate degree from The University of California at Berkeley. The latter was awarded in 1994 for structural studies on proteins involved in bacterial gene regulation using NMR spectroscopy. Dr. Volkman's postdoctoral training was in the Department of Biochemistry at the University of Wisconsin-Madison. In 2000, Dr. Volkman started at the 91九色视频 where he is Professor in the Biochemistry Department. Dr. Volkman's work focuses on the structural biology of immunological signaling molecules and the use of NMR spectroscopy in structural proteomics.

Research Experience

  • Amino Acid Sequence
  • Binding Sites
  • Chemokine CCL21
  • Chemokine CXCL12
  • Chemokines
  • Chemokines, C
  • Chemokines, CXC
  • Chemotaxis
  • Computational Biology
  • Crystallography, X-Ray
  • Dimerization
  • Drug Design

Research Interests

Our goal is to invent new ways to treat cancer and other ailments by examining the three-dimensional architecture of proteins involved in disease and synthesizing new drug candidate molecules. This research links the expertise of chemists, structural biologists, and clinician-scientists who collaborate in the design and testing of potential therapies. Graduate students in my group have invented and patented new compounds that show promise as treatments for cancer and psoriasis. Your donation helps us accelerate the drug development process by paying for preclinical studies that most research grants simply won’t support - bridging the gap between our basic science discoveries and clinical trials. 

We use NMR spectroscopy and many other techniques to (1) understand the transmission of biological signals in terms of molecular structure, recognition and dynamics and (2) exploit this knowledge for the design and discovery of new molecules with practical utility as research tools, bioactive nanomaterials, or new drugs.

Dynamics and folding. Protein function is exquisitely dependent on compactly folded structures that combine energetic stability with intrinsic flexibility. Our work has revealed surprising and altered the established paradigm for protein folding to include the new category of . We are now trying to define the and evolutionary origins of metamorphic folding using the divergence of human lymphotactin from the rest of the chemokine family as a prototypical example. Other projects analyze novel modes of conformational switching that control and enzyme activity.

Molecular recognition. Biological signals are often controlled by promoting or disrupting the interaction between two proteins. Many chemokines have been directly implicated in human diseases. Compounds that might function as inhibitors of inflammation, , viral infection or autoimmune disease. We recently used NMR to solve the , and subsequently used the details of this interface to search for that bind the chemokine and block its activity. A to inhibitor screening is now being used to with the ultimate goal of drug discovery to treat and psoriasis.

Lab Photo

Volkman Lab

Back Row L. to R.: Chris Veldkamp, Francis Peterson, Rob Tyler, Anthony Getschman (hands), Austin Jiang,
Alex Chadwick, Davin Jensen, Dustin Whitney and Josh Weiner
Middle Row L. to R.: Chad Koplinski, Amanda Nevins
First Row L. to R.: Dr. Brian Volkman, Echo the dog, Jamie Wieting, Becky Holme

Publications

  • (Luís R, Volkman BF, Szpakowska M, Chevigné A.) J Leukoc Biol. 2025 Apr 23;117(4) PMID: 39903605 PMCID: PMC12017343 02/04/2025

  • (Syed M, Dishman AF, Volkman BF, Walker TL.) Protein Sci. 2025 Feb;34(2):e70032 PMID: 39840812 PMCID: PMC11751857 SCOPUS ID: 2-s2.0-85215400606 01/22/2025

  • (Zhang BB, Harrison K, Zhong Y, Maxwell JWC, Ford DJ, Calvey LP, So SS, Peterson FC, Volkman BF, Stone MJ, Bhusal RP, Kulkarni SS, Payne RJ.) J Am Chem Soc. 2024 Dec 18;146(50):34253-34259 PMID: 39629944 SCOPUS ID: 2-s2.0-85211025577 12/04/2024

  • (Zhang X, Schlimgen RR, Singh S, Tomani MP, Volkman BF, Zhang C.) Proc Natl Acad Sci U S A. 2024 Nov 26;121(48):e2405732121 PMID: 39565315 PMCID: PMC11621518 SCOPUS ID: 2-s2.0-85210106138 11/20/2024

  • (Perez Almeria CV, Otun O, Schlimgen R, Lamme TD, Crudden C, Youssef N, Musli L, Jenjak S, Bobkov V, Drube J, Hoffmann C, Volkman BF, Granier S, Bechara C, Siderius M, Heukers R, Schafer CT, Smit MJ.) bioRxiv. 2024 Nov 04 PMID: 39574661 PMCID: PMC11580867 11/22/2024

  • (Xu T, Schou AS, Lackman JJ, Barrio-Calvo M, Verhallen L, Goth CK, Jensen BAH, Veldkamp CT, Volkman BF, Peterson FC, Hjortø GM.) Int J Mol Sci. 2024 Oct 09;25(19) PMID: 39409188 PMCID: PMC11477141 SCOPUS ID: 2-s2.0-85206465330 10/16/2024

  • (Pontejo SM, Martinez S, Zhao A, Barnes K, de Anda J, Alimohamadi H, Lee EY, Dishman AF, Volkman BF, Wong GCL, Garboczi DN, Ballesteros A, Murphy PM.) bioRxiv. 2024 Jul 25 PMID: 39091850 PMCID: PMC11291121 08/02/2024

  • (Schlimgen RR, Peterson FC, Heukers R, Smit MJ, McCorvy JD, Volkman BF.) Nat Commun. 2024 May 30;15(1):4611 PMID: 38816420 PMCID: PMC11139983 SCOPUS ID: 2-s2.0-85194992751 05/31/2024

  • (Zhang BB, Harrison K, Zhong Y, Maxwell JWC, Ford DJ, Calvey LP, So SS, Peterson FC, Volkman BF, Stone MJ, Bhusal RP, Kulkarni SS, Payne RJ.) Journal of the American Chemical Society. 18 December 2024;146(50):34253-34259 SCOPUS ID: 2-s2.0-85211025577 12/18/2024

  • (Park SY, Qiu J, Wei S, Peterson FC, Beltrán J, Medina-Cucurella AV, Vaidya AS, Xing Z, Volkman BF, Nusinow DA, Whitehead TA, Wheeldon I, Cutler SR.) Nat Chem Biol. 2024 Jan;20(1):103-110 PMID: 37872402 PMCID: PMC10746540 SCOPUS ID: 2-s2.0-85174576715 10/24/2023

  • (Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Front Genet. 2023;14:1291307 PMID: 38090150 PMCID: PMC10715303 SCOPUS ID: 2-s2.0-85179362461 12/13/2023

  • (Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2023;21:5249-5258 PMID: 37954151 PMCID: PMC10632586 11/13/2023

Publications of from the

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